Impact of Molecular Symmetry/Asymmetry on Insulin-Sensitizing Treatments for Type 2 Diabetes
نویسندگان
چکیده
Although the advantages and disadvantages of asymmetrical thiazolidinediones as insulin-sensitizers have been well-studied, relevance symmetry asymmetry for biguanides has scarcely explored. Regarding symmetrical molecules, only one thiazolidinedione no evaluated proposed an antihyperglycemic agent treating type 2 diabetes. Since molecular structure defines physicochemical, pharmacological, toxicological properties, it is important to gain greater insights into poorly investigated patterns. For example, compounds with intrinsic antioxidant properties commonly low toxicity. Additionally, ligands are each associated affinity certain types receptors. An advantageous response obtained in therapeutic application may imply a poor or even adverse effect another. Within context general patterns, compound must be assessed individually. The current review aimed summarize available evidence utilizing insulin sensitizers patients Other applications these same also examined well various uses additional molecules. More research needed exploit potential molecules sensitizers.
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ژورنال
عنوان ژورنال: Symmetry
سال: 2022
ISSN: ['0865-4824', '2226-1877']
DOI: https://doi.org/10.3390/sym14061240